Placental transfer of olanzapine occurred in rat pups. In postmarketing reports of overdose with olanzapine alone, symptoms have been reported in the majority of cases. Olanzapine displays linear kinetics over the clinical dosing range.
The following table demonstrates the appropriate individual component doses of ZYPREXA and fluoxetine versus Symbyax. Dosage adjustments, if indicated, should be made with the individual components according to efficacy and tolerability. Zyprexa be given marketing authorisation. What are the possible side effects of Zyprexa? This medicine may add to the effects of alcohol and other central nervous system CNS depressants medicines that make you drowsy or less alert. Some examples of CNS depressants are antihistamines or medicines for allergies or colds, sedatives, tranquilizers, or sleeping medicines, prescription pain medicines or narcotics, medicines for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any CNS depressants while you are taking this medicine.
Use Zyprexa Intramuscular as directed by your doctor. Check the label on the medicine for exact dosing instructions. This device is intended for injection or aspiration of fluids. The needle protection device covers the needle after use to help prevent needle sticks. None of these patients experienced jaundice or other symptoms attributable to liver impairment and most had transient changes that tended to normalize while Zyprexa Relprevv treatment was continued.
Eli Lilly and Company has received reports of fatality in association with overdose of oral olanzapine alone. Common side effects of Zyprexa include: lack of energy, dry mouth, increased appetite, sleepiness, tremor shakes having hard or infrequent stools, dizziness, changes in behavior, or restlessness. Lab tests, including fasting blood glucose, cholesterol, complete blood cell counts, and liver function, may be performed while you use Zyprexa Intramuscular. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
Some of your symptoms of schizophrenia may improve with treatment with Zyprexa Relprevv. If you do not think you are getting better, call your doctor. Clinically significant weight gain was observed across all baseline BMIs. Patients and caregivers should be counseled that a potentially fatal symptom complex sometimes referred to as NMS has been reported in association with administration of antipsychotic drugs, including Zyprexa. FOR DEEP INTRAMUSCULAR GLUTEAL INJECTION ONLY. In clinical studies, most adolescents were nonsmokers and this population had a lower average body weight, which resulted in higher average olanzapine exposure compared to adults.
If you notice any of these symptoms in your especially during their first month, tell the doctor right away. There is no general agreement about specific pharmacological treatment regimens for NMS. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Zyprexa Intramuscular is to be used only by the patient for whom it is prescribed. Do not share it with other people. Olanzapine has not been evaluated or used to any appreciable extent in patients with a recent history of myocardial infarction or unstable heart disease. Patients with these diagnoses were excluded from premarketing clinical studies. Patients should be advised of the potential risk of hyperglycemia-related adverse reactions related to Zyprexa Relprevv. Patients should be monitored regularly for worsening of glucose control. venlafaxine
To prevent serious side effects, do not stop taking Zyprexa suddenly. Zyprexa Relprevv and have their WBC followed until recovery. Zyprexa Relprevv is a long-acting prescription medicine given by injection and used to treat schizophrenia in adults. In vitro studies utilizing human liver microsomes suggest that olanzapine has little potential to inhibit CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A. Thus, olanzapine is unlikely to cause clinically important drug interactions mediated by these enzymes. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. None of these patients experienced jaundice or other symptoms attributable to liver impairment and most had transient changes that tended to normalize while olanzapine treatment was continued. Examination of population subsets race and gender did not reveal any differential responsiveness on the basis of these subgroupings. Given these considerations, olanzapine should be prescribed in a manner that is most likely to minimize the occurrence of tardive dyskinesia. However, the efficacy of repeated doses of intramuscular olanzapine for injection in agitated patients has not been systematically evaluated in controlled clinical trials. Slowly withdraw the desired amount into the syringe. All four studies lasted six weeks, but the patients stayed on the medicine for up to a year or more. In the treatment of acute manic episodes in adults with bipolar disorder, Zyprexa tablets were compared with placebo, haloperidol or valproate another medicine used in manic episodes in five studies, including one where patients were also receiving other medicines. Olanzapine appears to have a greater association than some other atypical antipsychotics for increasing glucose levels. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. The safety and efficacy of olanzapine have not been established in patients under the age of 13 years. Mean increase in weight in adolescents was greater than in adults. In 4 placebo-controlled trials, discontinuation due to weight gain occurred in 1% of olanzapine-treated patients, compared to 0% of placebo-treated patients. High blood sugar hyperglycemia. The terms alanine aminotransferase ALT aspartate aminotransferase AST and hepatic enzyme were combined under liver enzymes. kuzen.info zithromax
When using Zyprexa and fluoxetine in combination, also refer to the Clinical Studies section of the package insert for Symbyax. Oral carcinogenicity studies were conducted in mice and rats. Refer to the table at right to determine the final volume to inject. Zyprexa Relprevv can cause sleepiness and may affect your ability to make decisions, think clearly, or react quickly. Do not drive, operate heavy machinery, or do other dangerous activities until you know how Zyprexa Relprevv affects you. You should not drive or operate heavy machinery for the rest of the day after each injection. Infrequent: cerebrovascular accident, vasodilatation. Call your doctor if your symptoms do not improve, or if they get worse while using olanzapine. Do not stop taking olanzapine suddenly without first talking to your doctor, even if you feel fine. You may have serious side effects if you stop taking olanzapine suddenly. Olanzapine did not influence the pharmacokinetics of diazepam or its active metabolite N-desmethyldiazepam. Scholey, A. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur. Elderly patients, particularly women, are most susceptible. Both the risk of developing the syndrome and the likelihood that it will become irreversible increase with the duration and total cumulative dose of neuroleptic therapy administered. However, patients may infrequently develop symptoms after relatively brief treatment periods at low dosages. If TD occurs during neuroleptic therapy, prompt withdrawal of the offending agent or at least a lowering of the dosage should be considered. TD symptoms may become more severe after drug discontinuation or a dosage reduction, but may gradually improve over months to years. In patients with preexisting drug-induced TD, initiating or increasing the dosage of neuroleptic therapy may temporarily mask the symptoms of TD but could eventually worsen the condition. Open the sachet and peel back the foil on the blister. Do not push the tablet through the foil. Zyprexa IntraMuscular olanzapine for injection is intended for intramuscular use only. There is no known treatment for established cases of tardive dyskinesia, although the syndrome may remit, partially or completely, if antipsychotic treatment is withdrawn. Antipsychotic treatment, itself, however, may suppress or partially suppress the signs and symptoms of the syndrome and thereby may possibly mask the underlying process. The effect that symptomatic suppression has upon the long-term course of the syndrome is unknown. Common side effects of Zyprexa Relprevv include: headache, sleepiness or drowsiness, weight gain, dry mouth, diarrhea, nausea, common cold, eating more increased appetite vomiting, cough, back pain, or pain at the injection site.
After insertion of the needle into the muscle, aspirate for several seconds to ensure that no blood appears. If any blood is drawn into the syringe, discard the syringe and the dose and begin with a new convenience kit. The injection should be performed with steady, continuous pressure. To help prevent clogging, a 19-gauge or larger needle must be used. High blood sugar may make you feel confused, drowsy, or thirsty. It can also make you flush, breathe faster, or have a fruit-like breath odor. If these symptoms occur, tell your doctor right away. Disruption of the body's ability to reduce core body temperature has been attributed to antipsychotic agents. It is not known if Zyprexa Relprevv is safe and effective in children under 18 years of age. Dosage adjustments, if indicated, should generally occur at intervals of not less than 24 hours, reflecting the procedures in the placebo-controlled trials. Since these neurotransmitters are involved in schizophrenia and in bipolar disorder, olanzapine helps to normalise the activity of the brain, reducing the symptoms of these diseases. How has Zyprexa been studied? Khan, I. A. Scuteflorins A and B, dihydropyranocoumarins from Scutellaria lateriflora. J Nat. How should I receive Zyprexa Relprevv? May cause side effects to become worse. Remove by grasping the Luer hub of the needle protection device with thumb and forefinger, keeping the free fingers clear of the end of the device containing the needle point. Patients and caregivers should be advised that elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Store at room temperature away from moisture, heat, and light. If the product is not used right away, it should be shaken vigorously to re-suspend. warticon
Patients taking olanzapine should be monitored regularly for worsening of glucose control. Patients starting treatment with olanzapine should undergo fasting blood glucose testing at the beginning of treatment and periodically during treatment. Any patient treated with atypical antipsychotics should be monitored for symptoms of hyperglycemia including polydipsia, polyuria, polyphagia, and weakness. Patients who develop symptoms of hyperglycemia during treatment with atypical antipsychotics should undergo fasting blood glucose testing. Do Not Reuse: Medical devices require specific material characteristics to perform as intended. These characteristics have been verified for single use only. Any attempt to re-process the device for subsequent re-use may adversely affect the integrity of the device or lead to deterioration in performance. This medication may cause problems in newborns if taken during pregnancy or while breastfeeding. If you are pregnant or become pregnant while taking this medication, you should talk to your doctor about other possible treatments for your condition. Hypodermic Needle-Pro needle with needle protection device. For obese patients, a 2-inch 50 mm 19-gauge or larger needle not included in convenience kit may be used. To help prevent clogging, a 19-gauge or larger needle must be used. Attach the new safety needle to the syringe prior to injection. Once the suspension has been removed from the vial, it should be injected immediately. For deep intramuscular gluteal injection only. Do not inject intravenously or subcutaneously. Select and prepare a site for injection in the gluteal area. After insertion of the needle into the muscle, aspirate for several seconds to ensure that no blood appears. If any blood is drawn into the syringe, discard the syringe and the dose and begin with a new convenience kit. The injection should be performed with steady, continuous pressure. Do not massage the injection site. Engage the needle safety device. Dispose of the vials, needles, and syringe appropriately after injection. The vial is for single-use only. Cmax and AUC of oral olanzapine by about 60%. As peak olanzapine levels are not typically obtained until about 6 hours after dosing, charcoal may be a useful treatment for olanzapine overdose. The prescriber should be aware that the figures in the tables and tabulations cannot be used to predict the incidence of side effects in the course of usual medical practice where patient characteristics and other factors differ from those that prevailed in the clinical trials. Similarly, the cited frequencies cannot be compared with figures obtained from other clinical investigations involving different treatments, uses, and investigators. The cited figures, however, do provide the prescribing physician with some basis for estimating the relative contribution of drug and nondrug factors to the adverse reaction incidence in the population studied. buy online mebendazole 500mg
The symptoms of schizophrenia may include thoughts of suicide or of hurting yourself or others. If you have these thoughts at any time, tell your doctor or go to an emergency room right away. There are no adequate and well-controlled trials with olanzapine in pregnant females. Seven pregnancies were observed during clinical trials with olanzapine, including 2 resulting in normal births, 1 resulting in neonatal death due to a cardiovascular defect, 3 therapeutic abortions, and 1 spontaneous abortion. Hypodermic Needle-Pro needle with needle protection device. The following table enumerates the percentage of patients with treatment-emergent extrapyramidal symptoms as assessed by categorical analyses of formal rating scales during controlled clinical trials comparing fixed doses of intramuscular olanzapine for injection with placebo in agitation. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your or local waste disposal company. In an oral olanzapine study in lactating, healthy women, olanzapine was excreted in breast milk. The physician should periodically reexamine the need for continued pharmacotherapy. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. NOT TO BE INJECTED INTRAVENOUSLY OR SUBCUTANEOUSLY. What should I do if I overdose on this medication? For specific information about the contraindications of lithium or valproate, refer to the Contraindications section of the package inserts for these other products. Compared to patients from adult clinical trials, adolescents were likely to gain more weight, experience increased sedation, and have greater increases in total cholesterol, triglycerides, LDL cholesterol, prolactin, and hepatic aminotransferase levels.
Multiple doses of olanzapine did not affect the pharmacokinetics of theophylline or its metabolites. Zyprexa IntraMuscular is intended for intramuscular use only. Do not administer intravenously or subcutaneously. Inject slowly, deep into the muscle mass. Olanzapine is a yellow crystalline solid, which is practically insoluble in water. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of olanzapine in children. However, safety and efficacy of olanzapine in children younger than 13 years of age have not been established. What is the most important information I should know about olanzapine Zyprexa, Zyprexa Zydis? Patients with the following MedDRA terms were counted in this category: abdominal pain, abdominal pain lower, abdominal pain upper. Dosage adjustments, if indicated, can be made according to efficacy and tolerability. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Lilly officials say the effectiveness of Zyprexa in elderly people with dementia has not been established. reductil price in france
The magnitude of the impact of this factor is small in comparison to the overall variability between individuals, and therefore dose modification is not routinely recommended. When using Zyprexa and fluoxetine in combination, also refer to the Drug Interactions section of the package insert for Symbyax. Fluvoxamine: Fluvoxamine, a CYP1A2 inhibitor, decreases the clearance of olanzapine. This results in a mean increase in olanzapine Cmax following fluvoxamine of 54% in female nonsmokers and 77% in male smokers. The mean increase in olanzapine AUC is 52% and 108%, respectively. Lower doses of olanzapine should be considered in patients receiving concomitant treatment with fluvoxamine. Zyprexa Relprevv Patient Care Program. You must agree to the rules of the Zyprexa Relprevv Patient Care Program before you register. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Plasma concentrations of olanzapine during the first injection interval may be lower than those maintained by a corresponding oral dose. Even though the concentrations are lower, the olanzapine concentrations remained within a therapeutically effective range and supplementation with orally administered olanzapine was generally not necessary in clinical trials. Omeprazole and rifampin may cause an increase in olanzapine clearance. BPRS total score, BPRS psychosis cluster, and CGI severity score; the highest olanzapine dose group was superior to placebo on the SANS. There was no clear advantage for the high-dose group over the medium-dose group. All of my life I have had anxiety and depression. I also have body dysmorphic disorder. I am 23 years old taking prozac and Buspar. These medicines have helped me. But This medication has changed my life. It is awesome! Remove the needle from the vial, holding the vial upright to prevent any loss of material. Refer to the table below to determine the amount of diluent to be added to powder for reconstitution of each vial strength. In all studies, the effectiveness of Zyprexa was assessed using various symptom-rating scales. What benefit has Zyprexa shown during the studies? Caution should be exercised in patients with signs and symptoms of hepatic impairment, in patients with pre-existing conditions associated with limited hepatic functional reserve, and in patients who are being treated with potentially hepatotoxic drugs. Eli Lilly and Company has received reports of fatality in association with overdose of olanzapine alone. There are no systematically collected data to specifically address how to switch patients with schizophrenia from other antipsychotics to Zyprexa Relprevv. estreva purchase now online canada
Discard any unused portion of reconstituted Zyprexa IntraMuscular. In clinical studies, changes in prolactin levels were found to be statistically significantly different based on dose, higher doses were associated with higher levels of prolactin. In a study of up to 12 weeks, plasma prolactin concentrations exceeded the upper limit of normal ULN in approximately 30% of patients who had normal baseline prolactin values. The majority of these elevations were mild, and remained below 2 x ULN. Zyprexa may cause somnolence, postural hypotension, motor and sensory instability, which may lead to falls and, consequently, fractures or other injuries. For patients with diseases, conditions, or medications that could exacerbate these effects, complete fall risk assessments when initiating antipsychotic treatment and recurrently for patients on long-term antipsychotic therapy. Patients should be counseled that weight gain has occurred during treatment with Zyprexa Relprevv. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Dose group differences with respect to weight gain have been observed. Zyprexa Relprevv in clinical studies. You may gain weight or have high cholesterol and triglycerides types of fat while taking this medicine, especially if you are a teenager. Your blood may need to be tested often. Visit your doctor regularly. Dystonia, Class Effect: Symptoms of dystonia, prolonged abnormal contractions of muscle groups, may occur in susceptible individuals during the first few days of treatment. The medicine can only be obtained with a prescription. How is Zyprexa used? Zyprexa Relprevv in Adults: Statistically significant within group mean changes for Zyprexa Relprevv, which were also significantly different from placebo, were observed for the following: eosinophils, monocytes, cholesterol, low-density lipoprotein LDL triglycerides, and direct bilirubin. There were no statistically significant differences between Zyprexa Relprevv and placebo in the incidence of potentially clinically significant changes in any of the laboratory values studied. Safety and effectiveness of Zyprexa in patients under 13 years of age have not been established. Olanzapine Monotherapy in Adults: An assessment of the premarketing experience for oral olanzapine revealed an association with asymptomatic increases in ALT, AST, and GGT. Avoid smoking cigarettes and using tobacco products as they may interfere with the effectiveness of this drug. Increased risk of death in elderly people who are confused, have memory loss and have lost touch with reality dementia-related psychosis. Zyprexa is not approved for treating psychosis in elderly people with dementia. Keep out of the reach of children.
Diagnosis was confirmed by the K-SADS-PL. Olanzapine is indicated for the treatment of moderate to severe manic episode. Therefore, concomitant olanzapine administration does not require dosage adjustment of lithium. Patients with the following COSTART terms were counted in this category: akathisia, hyperkinesia. After procedure is completed, press the needle into the sheath using a one-handed technique. Perform a one-handed technique by gently pressing the sheath against a flat surface. The combined effects of age, smoking, and gender could lead to substantial pharmacokinetic differences in populations. The clearance in young smoking males, for example, may be 3 times higher than that in elderly nonsmoking females. This medicine may increase your weight. Your doctor may need to check your or your child's weight on a regular basis while you are using this medicine. Zyprexa has not been approved for use in children under 13 years of age. Zyprexa in combination with fluoxetine has not been approved for use in children under 10 years of age. order cefixime canada online
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Avoid drinking alcohol while taking Zyprexa. Drinking alcohol while you take Zyprexa may make you sleepier than if you take Zyprexa alone. After receiving Zyprexa Relprevv, you will need to stay at the clinic for at least 3 hours. Zyprexa Relprevv is a powder for suspension for intramuscular use only. Select and prepare a site for injection in the gluteal area. Lilly spokesman says this "off-label" use of the drug may account for up to 2% of all Zyprexa use. diphenhydramine
N-desmethyl olanzapine, present at steady state at 31% of the concentration of olanzapine. Both metabolites lack pharmacological activity at the concentrations observed. Other symptoms noted include extrapyramidal symptoms, dysarthria, ataxia, aggression, dizziness, weakness, hypertension, and convulsion. The potential for onset of an event is greatest within the first hour. The majority of cases have occurred within the first 3 hours after injection; however, the event has occurred after 3 hours. What should I avoid while taking Zyprexa?
Clinically significant weight gain was observed across all baseline Body Mass Index BMI categories. Keep Zyprexa away from light. Patients with the following MedDRA terms were counted in this category: lower respiratory tract infection, respiratory tract infection, respiratory tract infection viral, upper respiratory tract infection, viral upper respiratory tract infection. The most common adverse reactions associated with the immediate-release products were postural hypotension, constipation, weight gain, dizziness, personality disorder, and akathisia. The most common adverse reactions associated with the extended-release IM injection included headache, sedation, weight gain, cough, diarrhea, back pain, nausea, somnolence, dry mouth, nasopharyngitis, increased appetite, and vomiting.
Avoid drinking alcohol while taking Zyprexa Relprevv. Drinking alcohol while you take Zyprexa Relprevv may make you sleepier than if you take Zyprexa Relprevv alone. Inject the diluent into the powder vial. There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Using dry hands, remove the tablet and place it in your mouth. It will begin to dissolve right away. In an analysis of patients who completed 12 months of therapy, the mean nonfasting total cholesterol did not increase further after approximately 4-6 months.